STK39

عدِّل

سرين ثريونين كيناز 39 (STE20/SPS1 homolog, yeast), ويعرف أيضا بإسم STK39, هو جين بشري. وقد أظهرت بعض الدراسات عن وجود إرتباط بين هذا الجين وإرتفاع ضغط الدم.

سيرين ثريونين كيناز 39 (STE20/SPS1 homolog, yeast)
المحددات
الرمزs	STK39; PASK; DCHT; DKFZp686K05124; SPAK
المحددات الخارجية	OMIM: 607648 MGI: 1858416 هومولوجين: 22739
طبيعة الجين الوظيفة الجزيئية • nucleotide binding • protein kinase activity • receptor signaling protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity المكون الخلوي • membrane fraction • nucleus • cytoplasm • basolateral plasma membrane • apical plasma membrane العملية الحيوية • protein amino acid phosphorylation • response to stress
نمط تعبير الرنا
المزيد من التعبيرات المرجعية
الكروموسومات المتناددة Orthologs
| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |- | bgcolor="#C3FDB8" | Entrez | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 27347 | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 53416 |- | bgcolor="#C3FDB8" | Ensembl | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000198648 | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000027030 |- | bgcolor="#C3FDB8" | Uniprot | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q9UEW8 | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3TR01 |- | bgcolor="#C3FDB8" | Refseq | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_013233 (mRNA) NP_037365 (protein) | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_016866 (mRNA) NP_058562 (protein) |- | bgcolor="#C3FDB8" | Location | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Chr 2: 168.52 - 168.81 Mb | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Chr 2: 68.01 - 68.27 Mb |- |- | bgcolor="#C3FDB8" | Pubmed search | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1] | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
النوع	بشري	فأري
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
الموقع (UCSC)	n/a	n/a
بحث PubMed	n/a	n/a

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 قراءات إضافية

• Johnston AM, Naselli G, Gonez LJ; et al. (2000). "SPAK, an STE20/SPS1-related kinase that activates the p38 pathway". Oncogene. 19 (37): 4290–7. doi:10.1038/sj.onc.1203784. PMID 10980603. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Qi H, Labrie Y, Grenier J; et al. (2001). "Androgens induce expression of SPAK, an STE20/SPS1-related kinase, in LNCaP human prostate cancer cells". Mol. Cell. Endocrinol. 182 (2): 181–92. PMID 11514053. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Dowd BF, Forbush B (2003). "PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)". J. Biol. Chem. 278 (30): 27347–53. doi:10.1074/jbc. M301899200. PMID 12740379. {{cite journal}}: Check |doi= value (help)
• Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase". J. Biol. Chem. 278 (52): 52848–56. doi:10.1074/jbc. M309436200. PMID 14563843. {{cite journal}}: Check |doi= value (help)CS1 maint: multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Moriguchi T, Urushiyama S, Hisamoto N; et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". J. Biol. Chem. 280 (52): 42685–93. doi:10.1074/jbc. M510042200. PMID 16263722. {{cite journal}}: Check |doi= value (help); Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Vitari AC, Thastrup J, Rafiqi FH; et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMID 16669787. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Polek TC, Talpaz M, Spivak-Kroizman TR (2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem. Biophys. Res. Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Yan Y, Nguyen H, Dalmasso G; et al. (2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochim. Biophys. Acta. 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMID 17321610. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)